P-21

Description

P-21 (also written P21 or P021) is a synthetic peptidergic compound derived from the biologically active region of ciliary neurotrophic factor (CNTF). It was engineered as a small, stable CNTF mimetic: an 11-residue core sequence carrying an adamantylated glycine that improves stability and blood–brain-barrier permeability relative to the parent protein. Unlike full-length CNTF, P-21 does not activate the leukemia inhibitory factor receptor and has been studied as a tool for probing neurotrophic signaling without the confounding effects of the whole cytokine. It is supplied here for controlled analytical and laboratory investigation of neurotrophic and neurogenesis pathways.

Research focus

• CNTF-mimetic and BDNF/TrkB neurotrophic signaling
• Adult hippocampal neurogenesis and synaptic plasticity models
• GSK-3β inhibition and tau phosphorylation pathways

This Medtruva catalog product is a laboratory research material, not a clinical product. Store and prepare it only according to an appropriate research protocol, and review all available documentation before use.

For laboratory research use only. Not for human consumption, diagnosis, treatment, or veterinary use.