Description
Scientific overview
Retatrutide (LY3437943) is an investigational, single-molecule peptide agonist engineered to activate three nutrient-responsive receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), glucagon-like peptide-1 receptor (GLP-1R), and glucagon receptor (GCGR). These class B G protein-coupled receptors participate in the regulation of pancreatic hormone secretion, appetite signaling, energy balance, and substrate metabolism.
Simultaneous GIPR, GLP-1R, and GCGR agonism is being studied as a strategy to integrate incretin signaling with glucagon-receptor-mediated effects on hepatic metabolism and energy expenditure. Retatrutide has undergone Phase 2 and Phase 3 clinical investigation across obesity and related cardiometabolic conditions; it remains investigational and is not approved for public use as of September 2026.
Research characteristics
- Molecular class: synthetic, long-acting peptide receptor agonist
- Primary targets: GIPR, GLP-1R, and GCGR
- Research focus: nutrient signaling, glucose and lipid metabolism, energy homeostasis, and body-composition biology
- Available research formats: 30 mg, 40 mg, and 50 mg
Research-use notice: Supplied for laboratory research only. Not for human or veterinary use, diagnosis, treatment, or consumption. No medical or therapeutic claims are made.




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